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Vaccin grippal quadrivalent : quels changements pour quels bénéfices ?

Identifieur interne : 000015 ( France/Analysis ); précédent : 000014; suivant : 000016

Vaccin grippal quadrivalent : quels changements pour quels bénéfices ?

Auteurs : Anne Mosnier [France] ; Odile Launay [France] ; Luc Martinez ; Gaetan Gavazzi [France] ; Laurence Josset [France] ; Pascal Crepey [France] ; Claude Hannoun ; Catherine Weil-Olivier [France] ; Jacques Gaillat [France]

Source :

RBID : Hal:hal-02461688

Descripteurs français

Abstract

Currently, circulating viruses responsible for annual seasonal influenza epidemics belong to two influenza A subtypes, A(H1N1) and A(H3N2), and to two antigenically distinct type B lineages, B/Yamagata and B/Victoria lineages. Like diseases due to influenza A virus, influenza B virus diseases may have severe consequences and should be prevented. Until now, in France, the vaccines used to prevent seasonal influenza were trivalent, systematically targeting viruses belonging to both A subtypes and to one or other of the B lineages. The protective efficacy of trivalent vaccines is diminished during the seasons when viruses belonging to both B lineages cocirculated or when the circulating dominant type B virus belonged to a lineage different from that targeted by the vaccine strain. By targeting viruses belonging to both B lineages, quadrivalent vaccines improve the antigenic concordance between circulating and vaccine type B strains. Three inactivated quadrivalent vaccines are authorized for marketing in France and should be available for the 2018-2019 season. It is expected that, by providing enlarged protection, these quadrivalent influenza vaccines will improve vaccine efficacy, the confidence in immunization of the public, the satisfaction of health professionals, and ultimately will help to complete immunization coverage.


Url:
DOI: 10.1016/j.lpm.2018.06.013


Affiliations:


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Hal:hal-02461688

Le document en format XML

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<series>
<title level="j">La Presse Médicale</title>
<idno type="ISSN">0755-4982</idno>
<imprint>
<date type="datePub">2018-10</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="mix" xml:lang="fr">
<term>Vaccin anti grippal</term>
<term>Vaccin grippal quadrivalent</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>Currently, circulating viruses responsible for annual seasonal influenza epidemics belong to two influenza A subtypes, A(H1N1) and A(H3N2), and to two antigenically distinct type B lineages, B/Yamagata and B/Victoria lineages. Like diseases due to influenza A virus, influenza B virus diseases may have severe consequences and should be prevented. Until now, in France, the vaccines used to prevent seasonal influenza were trivalent, systematically targeting viruses belonging to both A subtypes and to one or other of the B lineages. The protective efficacy of trivalent vaccines is diminished during the seasons when viruses belonging to both B lineages cocirculated or when the circulating dominant type B virus belonged to a lineage different from that targeted by the vaccine strain. By targeting viruses belonging to both B lineages, quadrivalent vaccines improve the antigenic concordance between circulating and vaccine type B strains. Three inactivated quadrivalent vaccines are authorized for marketing in France and should be available for the 2018-2019 season. It is expected that, by providing enlarged protection, these quadrivalent influenza vaccines will improve vaccine efficacy, the confidence in immunization of the public, the satisfaction of health professionals, and ultimately will help to complete immunization coverage.</p>
</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>France</li>
</country>
</list>
<tree>
<noCountry>
<name sortKey="Hannoun, Claude" sort="Hannoun, Claude" uniqKey="Hannoun C" first="Claude" last="Hannoun">Claude Hannoun</name>
<name sortKey="Martinez, Luc" sort="Martinez, Luc" uniqKey="Martinez L" first="Luc" last="Martinez">Luc Martinez</name>
</noCountry>
<country name="France">
<noRegion>
<name sortKey="Mosnier, Anne" sort="Mosnier, Anne" uniqKey="Mosnier A" first="Anne" last="Mosnier">Anne Mosnier</name>
</noRegion>
<name sortKey="Crepey, Pascal" sort="Crepey, Pascal" uniqKey="Crepey P" first="Pascal" last="Crepey">Pascal Crepey</name>
<name sortKey="Gaillat, Jacques" sort="Gaillat, Jacques" uniqKey="Gaillat J" first="Jacques" last="Gaillat">Jacques Gaillat</name>
<name sortKey="Gavazzi, Gaetan" sort="Gavazzi, Gaetan" uniqKey="Gavazzi G" first="Gaetan" last="Gavazzi">Gaetan Gavazzi</name>
<name sortKey="Josset, Laurence" sort="Josset, Laurence" uniqKey="Josset L" first="Laurence" last="Josset">Laurence Josset</name>
<name sortKey="Launay, Odile" sort="Launay, Odile" uniqKey="Launay O" first="Odile" last="Launay">Odile Launay</name>
<name sortKey="Weil Olivier, Catherine" sort="Weil Olivier, Catherine" uniqKey="Weil Olivier C" first="Catherine" last="Weil-Olivier">Catherine Weil-Olivier</name>
</country>
</tree>
</affiliations>
</record>

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